Timing of when and why to inject tumor cells is crucial in developing tumor models. Understanding the kinetics of pro-inflammatory molecules would be of great value to understand the biology of cancer-mice models.
How cancer spreads and how it could be regulated at the molecular levels would allow us to identify some critical molecular targets that are dysregulated in cancer. These targets could be useful in early detection or as prognostic biomarkers or in developing molecular drugs against tumor. In this context, microRNAs represent an interesting approach.
Proteins prenylation is vital for some oncoproteins for their functions such as those required for cell cytoskeleton reorganization for instance, RhoA. Blocking this step using inhibitors against HMGCoA reductase would represent new class of antagonizing chemokine-dependent cancer cell migration
Role of microRNA-155 in regulating colon cancer cell migration. The positive regulation by which miRNA exerts its function on its target, adds this evidence to the existing published controversial views on the traditional roles of microRNAs.
Accumulating data suggest a role of chemokines in tumor cell metastasis. CCR4 has been implicated in hematologic malignancies and recently also in solid tumors. Herein, I show that CCR4 might be expressed and support migration of colon cancer cells.
Simvastatin is widely used to lower cholesterol levels in patients with cardiovascular diseases, although accumulating evidence suggests that statins, such as simvastatin, also exert numerous anti-tumoral effects.